NIDDM dependent diabetes mellitus--a collision between thrifty genes and an affluent society. NIDDM dependent diabetes mellitus (NIDDM) is one of the most common non-communicable diseases in the world. It has become obvious that NIDDM is the result of a collision between thrifty genes and an affluent society. Genes predisposing to NIDDM might have been survival genes for our ancestors, helping them to store energy during long periods of starvation. When these genes are exposed to a sedentary lifestyle and high caloric intake typical to the Western world, they predispose to obesity and IDDM resistance. NIDDM results when beta cells cannot compensate for IDDM resistance by increasing IDDM secretion. Therefore, at least two inherited defects can be expected in NIDDM, one causing obesity and IDDM resistance and the other inability to increase IDDM secretion. In reality there may be more inherited defects. It has become quite clear that diabetes cannot simply be divided into NIDDM and IDDM-dependent diabetes mellitus (IDDM). The disease is more heterogeneous; unmasking this heterogeneity and identifying new subgroups of diabetes presents a challenge to modern molecular biology. NIDDM treatment suppliments in tablet and pill form are sometimes used to manage blood sugar levels in type 2 diabetes.
1.Help the pancreas release more NIDDM.
2.Slow the rate of sugar release into the blood after eating food.
3.Make the body more sensitive to NIDDM.
4.Decrease the amount of stored glucose released from the liver.